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Addressing missing data in clinical trials.

Overview
Title:
Addressing missing data in clinical trials.
Authors:
Fleming TR
Journal:
Ann. Intern. Med.
Publication date:
2011
Volume:
154
Issue:
2
First page:
113
Last page:
7
ISSN:
1539-3704
Link to pubmed:
http://www.ncbi.nlm.nih.gov/pubmed/21242367
Publication type:
Journal
Free text

The reliability and interpretability of results from clinical trials can be substantially reduced by missing data. Frequently used approaches to address these concerns, such as upward adjustments in sample sizes or simplistic methods for handling missing data, including last-observation-carried-forward, complete-case, or worst-case analyses, are usually inadequate. Although rational imputation methods may be useful to treat missingness after it has occurred, these methods depend on untestable assumptions. Thus, the preferred and often only satisfactory approach to addressing missing data is to prevent it. Procedures should be in place to maximize the likelihood that outcome data will be obtained at scheduled times of evaluation for all surviving patients who have not withdrawn consent. To meaningfully reduce missing data, it is important to recognize and address many factors that commonly lead to higher levels of missingness.

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Addressing missing data in clinical trials. Fleming TR. Ann. Intern. Med. 2011; 154(2):113-7.

Page last updated: Apr 02, 2011
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