Book Navigation

GRADE guidelines: 3. Rating the quality of evidence.

Overview
Title:
GRADE guidelines: 3. Rating the quality of evidence.
Authors:
Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J, Vist GE, Falck-Ytter Y, Meerpohl J, Norris S, Guyatt GH
Journal:
J Clin Epidemiol.
Publication date:
2011 Apr
Volume:
64
Issue:
4
First page:
401
Last page:
6
Link to pubmed:
http://www.ncbi.nlm.nih.gov/pubmed/21208779
Publication type:
Journal
Abstract
This article introduces the approach of GRADE to rating quality of evidence. GRADE specifies four categories-high, moderate, low, and very low-that are applied to a body of evidence, not to individual studies. In the context of a systematic review, quality reflects our confidence that the estimates of the effect are correct. In the context of recommendations, quality reflects our confidence that the effect estimates are adequate to support a particular recommendation. Randomized trials begin as high-quality evidence, observational studies as low quality. "Quality" as used in GRADE means more than risk of bias and so may also be compromised by imprecision, inconsistency, indirectness of study results, and publication bias. In addition, several factors can increase our confidence in an estimate of effect. GRADE provides a systematic approach for considering and reporting each of these factors. GRADE separates the process of assessing quality of evidence from the process of making recommendations. Judgments about the strength of a recommendation depend on more than just the quality of evidence.
Preview

GRADE guidelines: 3. Rating the quality of evidence. Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J et al. J Clin Epidemiol. 2011 Apr; 64(4):401-6.

Page last updated: Oct 13, 2011
Copyright © 2002-2016 Guidelines International Network.
All rights reserved

The Guidelines International Network is formally constituted as a Scottish Guarantee Company under Company Number SC243691 and recognised as a Scottish Charity under Scottish Charity Number SC034047 with its Registered Office at J. & H. Mitchell W.S., 51 Atholl Road, Pitlochry, Perthshire PH16 5BU, Scotland.

Back to top